SERUM URIC ACID AS AN INDEPENDENT RISK FACTOR IN ACUTE ISCHEMIC STROKE: A CROSS-SECTIONAL STUDY

Abstract

Background: Stroke is a leading cause of mortality and disability worldwide, with ischemic stroke accounting for the majority of cases. Serum uric acid (SUA), a product of Purine metabolism, has been implicated in cardiovascular and cerebrovascular diseases. However, its role as an independent risk factor remains controversial. Objectives: To assess the relationship between serum uric acid and other risk factors such as hypertension, diabetes mellitus, and coronary artery disease with acute ischemic stroke. Methods: A hospital-based cross-sectional study was conducted on 97 patients presenting with first-ever acute ischemic stroke. Serum uric acid levels were measured within 24 hours of admission. Clinical and biochemical parameters were analyzed. Statistical associations were evaluated using chi-square test and correlation analysis. Results: Elevated serum uric acid levels were observed in a significant proportion of patients with acute ischemic stroke. Hyperuricemia showed a statistically significant association with hypertension and diabetes mellitus (p < 0.05). Patients with higher SUA levels had increased stroke severity and associated comorbidities. Conclusion: Serum uric acid may serve as an independent risk factor for acute ischemic stroke and is strongly associated with traditional cardiovascular risk factors.